Beilstein J. Org. Chem.2013,9, 215–222, doi:10.3762/bjoc.9.25
phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved greatly beneficial for the inhibitory potency.
Keywords: multivalentcarbohydrates; LecA inhibition; phenylene ethynylene
obtained after deprotection of the alkyne moieties with K2CO3.
Preliminary application
As part of our program on bacterial adhesion inhibition by multivalentcarbohydrates, the bacterial lectin LecA, a virulence factor of the problematic pathogen Pseudomonas aeruginosa is a target of interest [30][31
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Graphical Abstract
Figure 1:
Schematic depiction of (a) a rigid phenylene-ethynylene polymer core with ligands attached via flex...